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Grant to a USA Nonprofit or IHE for
Research Related to Infectious Diseases

National Priorities: Innovative Sampling Designs for Public Health Surveillance of Coronaviruses and Other Pathogens in Wastewater

Agency Type:


Funding Source:

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U.S. Environmental Protection Agency (EPA) - Office of Science Advisor, Policy and Engagement - Office of Research and Development

Conf. Date:


Deadline Date:

12/15/21 11:59 PM Eastern


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Grant to a USA nonprofit organization or institution of higher education for research related to infectious diseases. Funding is intended for studies that explore effective wastewater sampling network designs that allow for early detection and offer evidence of the spread of infection from national to local levels in a form that can be readily used by public health agencies to address current and future epidemics/pandemics.

Wastewater sampling has been widely deployed during the COVID-19 pandemic as a cost-effective, screening-level approach to assess infection levels in the community. In addition to improved analytical detection methods and understanding of pathogen fate and transport in sewer systems, advancing wastewater-based monitoring will require well-designed sampling networks and public health data integration approaches.

For additional information about developing wastewater sampling networks, see: For additional eligibility information, see:

The proposal seeks research to inform wastewater monitoring sampling designs rather than standardization of methods. However, evaluation of proposed designs using existing data collected during the pandemic is strongly encouraged. This evaluation should include the following considerations:

  1. Use of established data collection methods while acknowledging limitations of data reported,
  2. Use of standardized approaches for analyzing COVID-19 data, and
  3. Understanding and reporting limitations of forecast models for COVID-19 using wastewater surveillance, including factors affecting SARS-CoV-2 in wastewater independent of infection rates (e.g., stormwater inflows in combined sewers, extended residence time and greater decay, industrial inputs caused by dilution, decay, and inhibition).

According to the CDC, the development of a wastewater surveillance sampling monitoring strategy should include:

  1. An assessment of public health data needs, such as detecting the presence of the pathogen and monitoring trends, including reported and unreported cases;
  2. Evaluating wastewater sampling and testing capacity; and
  3. Developing a sampling plan, including what and where to sample and how often to take samples.

For information about required research areas, see:

GrantWatch ID#:

GrantWatch ID#: 199208

Estimated Total Program Funding:


Number of Grants:


Estimated Size of Grant:

Up to $1,000,000

Term of Contract:

Maximum duration of 3 years.

Additional Eligibility Criteria:

Public and private nonprofit institutions and public and private universities and colleges located in the United States and its territories or possessions are eligible.

Foreign entities, States, the District of Columbia, State and local government departments, territories, possessions, and Federally Recognized Indian Tribal Governments of the U.S., are not eligible to apply under this Request for Applications (RFA). Profit-making firms and individuals are not eligible to receive assistance agreements from the EPA under this program.

EPA strongly encourages all eligible applicants including minority-serving institutions (MSIs), to apply under this opportunity. For additional information about MSIs, see:

For additional eligibility information, see:

Federal Agencies may not apply. Federal employees are not eligible to serve in a principal leadership role on an assistance agreement.

Pre-proposal Conference:

An informational webinar will be held on Tuesday, November 9, 2021, 1:00 pm - 2:00 pm EST.

Register here:

Pre-Application Information:

The deadline to apply on is December 15, 2021, by 11:59 PM Eastern Time.

If your organization is not currently registered with, you need to allow approximately one month to complete the registration process. Please note that the registration process also requires that your organization have a DUNS number and current registration with the System for Award Management (SAM) and the process of obtaining both could take a month or more.

Cost-sharing is required. Applications with budgets including a federal contribution exceeding the total maximum federal award limit will not be considered. Each applicant must contribute a minimum non-federal cost share/match of 25% of the federal funds awarded. This is equivalent to a minimum of 20% of the total project costs. Cost-share may include in-kind contributions.

Applications submitted under this announcement shall include a Scientific Data Management Plan (SDMP) that addresses public access to EPA-funded scientific research data.

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For a list of application documents, see the Package tab (press Preview) on the page above.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Technical Contact: Rich Callan; phone: 202-564-4191; email:

Eligibility Contact: Ron Josephson; phone: 202-564-7823; email:

Electronic Submissions Contact: Debra M. Jones; phone: 202-564-7839; email:

CFDA Number:


Funding or Pin Number:

Funding Opportunity Number: EPA-G2022-ORD-B1

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

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