Pediatric Sarcomas

The Samuel Waxman Cancer Research Foundation (SWCRF), Alan B. Slifka Foundation (ABSF) and Israel Cancer Research Fund (ICRF) are pleased to issue a joint Request for Applications (RFA) for collaborative applications focused on fusion-positive pediatric sarcomas. Projects must involve collaboration between two research groups — one in North America and one in Israel — with different but complementary expertise. Proposals must justify the partnership through synergistic scientific aims.

Proposals will be prioritized for funding based on their potential to contribute to understanding, preventing and effectively treating pediatric sarcomas, with an emphasis on Ewing sarcoma. Appropriate research topics will include, but are not limited to:

• Metastatic disease and how to prevent or treat metastasis
• Relapsed disease and how to prevent metastasis
• The Ewing oncoprotein EWS/FLI and its roles in tumor development
• Discovery of new pathways, targets and biomarkers for diagnosis and treatment
• Development of improved technologies for delivery of therapies to tumor cells

Recipients of these awards are encouraged to develop collaborations that extend beyond the original team and terms of the grant and form a community of investigators committed to:

• Collaboration
• Sharing of research materials, reagents and/or core resources
• Joint publications
• Development of program project grants (P01s) and/or collaborative R01s
• Development of new research projects that enhance other programs funded by SWCRF, ABSF and ICRF.
• Communication
• Presentation at the annual Connective Tissue Oncology Society (CTOS) meeting
• Interactions at the annual SWCRF Scientific Review Meeting